HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda.
Daniel J KyabayinzeIssaka ZongoJane CunninghamMichelle L GattonPatrick AngutokoJohn AtegekaYves-Daniel CompaoréAtis MuehlenbachsJerry MulondoMiriam NakalembeFabrice A SoméAminata OuattaraNoél RouambaJean-Bosco OuédraogoHeidi HopkinsDavid BellPublished in: PloS one (2016)
The study suggests that HRP2-based RDTs are the most appropriate point-of-care test currently available for use during pregnancy especially for symptomatic women, but will still miss some PCR-positive women. The clinical significance of these very low density infections needs to be better defined.
Keyphrases
- polycystic ovary syndrome
- real time pcr
- loop mediated isothermal amplification
- pregnancy outcomes
- label free
- cervical cancer screening
- high resolution
- breast cancer risk
- high throughput
- high speed
- skeletal muscle
- metabolic syndrome
- optical coherence tomography
- mass spectrometry
- quantum dots
- adipose tissue
- clinical practice