The development of a cSMART-based integrated model for hepatocellular carcinoma diagnosis.
Tong WuRong FanJian BaiZhao YangYun-Song QianLu-Tao DuChun-Ying WangYing-Chao WangGuo-Qing JiangDan ZhengXiao-Tang FanBo ZhengJing-Feng LiuGuo-Hong DengFeng ShenHe-Ping HuYi-Nong YeQing-Zheng ZhangJing ZhangYan-Hang GaoJie XiaHua-Dong YanMin-Feng LiangYan-Long YuFu-Ming SunYu-Jing GaoJian SunChun-Xiu ZhongYin WangHui WangFei KongJin-Ming ChenHao WenBo-Ming WuChuan-Xin WangLin WuJin-Lin HouXiao-Long LiuHong-Yang WangLei ChenPublished in: Journal of hematology & oncology (2023)
An integrated diagnostic model called "Combined method" was developed by combining three mutation sites and three serum biomarkers. Combined method outperformed AFP in the diagnosis of HCC, especially early HCC, with sensitivities of 81.25% for all stages and 66.67% for early HCC, respectively. Importantly, the integrated model exhibited high accuracy in differentiating AFP-negative, AFP-L3-negative, and PIVKA-II-negative HCCs from LCs.
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