Epstein-Barr Virus in the Cerebrospinal Fluid and Blood Compartments of Patients With Multiple Sclerosis and Controls.

Joonas Lehikoinen Katariina Nurmi Mari AinolaJonna ClancyJanne K NieminenLilja JanssonHanna VauhkonenAntti VaheriTeemu SmuraSini M LaaksoKari K EklundPentti J Tienari

Published in: Neurology(R) neuroimmunology & neuroinflammation (2024)

EBV-DNA is equally detectable in the CSF cells of both patients with MS and controls with ddPCR, and the probabilistic approach indicates that the true positivity rate approaches 100% in EBV-positive individuals. The proportion of EBV-positive B cells seems higher than previously estimated.

Keyphrases

epstein barr virus
cerebrospinal fluid
diffuse large b cell lymphoma
induced apoptosis
cell cycle arrest
mass spectrometry
multiple sclerosis
ms ms
circulating tumor
single molecule
oxidative stress
cell death
signaling pathway