Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival.

Calixto-Hope G LucasHarish N VasudevanWilliam C ChenStephen T MagillSteve E BraunsteinLine Jacques Jeffrey R Millman Fausto J RodriguezAndrew E HorvaiArie PerryMelike PekmezciDavid R Raleigh

Published in: Neuro-oncology advances (2020)

Our results lend support to the FNCLCC sarcoma grading criteria as a prognostic scheme for MPNST, although few cases of grade 1 were included. Further, we identify increased Ki-67 labeling as a strong predictor of poor OS from MPNST. Finally, we identify a subset of MPNSTs with a predictive immunohistochemical profile that has improved local control with adjuvant radiotherapy. These data provide insights into the grading and therapy for patients with MPNST, although further studies are needed for independent validation.

Keyphrases

peripheral nerve
early stage
locally advanced
radiation therapy
radiation induced
neoadjuvant chemotherapy
electronic health record
rectal cancer
big data
machine learning
data analysis