Somatostatin signalling promotes the differentiation of rod photoreceptors in human pluripotent stem cell-derived retinal organoid.

Mingkang ChenXiying MaoDarui HuangJiaona JingWenjun ZouPeiyao MaoMengting XueWenjie YinRuiwen ChengYan GaoYoujin HuSongtao YuanQing-Huai Liu

Published in: Cell proliferation (2022)

Our study identified SSTR2 signalling as a novel extrinsic regulator for rod photoreceptor fate determination in photoreceptor precursors, which expands the repertoire of functional signalling pathways in photoreceptor development and sheds light on the optimization of the photoreceptor enrichment strategy.

Keyphrases

endothelial cells
optical coherence tomography
diabetic retinopathy
transcription factor
induced pluripotent stem cells
solid phase extraction