DKK1 is a strong candidate for mesiodens and taurodontism.
Piranit Nik KantaputraPeeranat JatooratthawichotNaomi KottegeRobert P AnthonappaMassupa KaewgahyaSissades TongsimaChumpol NgamphiwJames R Ketudat CairnsDanilo PredesXi HePublished in: Clinical genetics (2023)
A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/β-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.