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DKK1 is a strong candidate for mesiodens and taurodontism.

Piranit Nik KantaputraPeeranat JatooratthawichotNaomi KottegeRobert P AnthonappaMassupa KaewgahyaSissades TongsimaChumpol NgamphiwJames R Ketudat CairnsDanilo PredesXi He
Published in: Clinical genetics (2023)
A mutation in DKK1 gene leads to inhibitory DKK1 function, over-activation of WNT/β-catenin signaling, disruptive development of dental epithelium, and subsequent mesiodens formation.
Keyphrases
  • stem cells
  • cell proliferation
  • genome wide
  • copy number
  • dna methylation
  • genome wide identification
  • genome wide analysis