Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases.
Nur Shafika Mohd SairaziSirajudeen Kuttulebbai Nainamohamed SalamPublished in: Evidence-based complementary and alternative medicine : eCAM (2020)
In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.
Keyphrases
- cell death
- cerebral ischemia
- amyotrophic lateral sclerosis
- type diabetes
- blood pressure
- multiple sclerosis
- brain injury
- subarachnoid hemorrhage
- cardiovascular disease
- blood brain barrier
- cell cycle arrest
- squamous cell carcinoma
- papillary thyroid
- risk assessment
- metabolic syndrome
- drug delivery
- glycemic control
- young adults
- cognitive decline
- human health
- combination therapy
- replacement therapy