Mendelian Randomization Analysis Reveals a Complex Genetic Interplay Among Atopic Dermatitis, Asthma, and GERD.

Kwangmi AhnRaymond B PennSatish RattanReynold A PanettieriBenjamin F VoightSteven S An

Published in: American journal of respiratory and critical care medicine (2022)

This study uncovers previously unrecognized causal pathways that have clinical implications in European-ancestry populations: 1) asthma is a causal risk for AD; and 2) the predisposition to AD, including asthma, can arise from specific pathogenic mechanisms manifested by GERD.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
atopic dermatitis
cystic fibrosis
genome wide
air pollution
gene expression
copy number
genome wide association study