Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative.
Aisling MinardClaudia C BauerEulashini Chuntharpursat-BonIsabelle B PicklesDavid J WrightMelanie J LudlowMatthew P BurnhamStuart L WarrinerDavid J BeechKatsuhiko MurakiRobin S BonPublished in: British journal of pharmacology (2019)
This study suggests the possibility for selective activation of TRPC5 channels by xanthine derivatives and supports the general principle that xanthine-based compounds can activate, potentiate, or inhibit these channels depending on subunit composition.