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Potent, selective, and subunit-dependent activation of TRPC5 channels by a xanthine derivative.

Aisling MinardClaudia C BauerEulashini Chuntharpursat-BonIsabelle B PicklesDavid J WrightMelanie J LudlowMatthew P BurnhamStuart L WarrinerDavid J BeechKatsuhiko MurakiRobin S Bon
Published in: British journal of pharmacology (2019)
This study suggests the possibility for selective activation of TRPC5 channels by xanthine derivatives and supports the general principle that xanthine-based compounds can activate, potentiate, or inhibit these channels depending on subunit composition.
Keyphrases
  • uric acid
  • vascular smooth muscle cells
  • metabolic syndrome
  • protein kinase
  • angiotensin ii