Modulation of monocyte activity by hepatocellular MicroRNA delivery through HBsAg particles: Implications for pathobiology of chronic hepatitis B.
Jin LiXiao MaQinkao XuanQiang LiMin WuBisheng ShiZhong FangLiang ChenJieliang ChenYumei WenChuanwu ZhuLi ZhuXiao-Nan ZhangZhenghong YuanPublished in: Hepatology (Baltimore, Md.) (2024)
HBsAg particles carry hepatocellular miRNAs, including miR-939, which enter monocytes and alter their functional status, such as IL-8 secretion. Our findings demonstrate that the HBsAg-miR-939-IL-8 axis may play a crucial role in HBV-induced hepatic necro-inflammation and the progression of advanced liver diseases.