Associations of maternal early-pregnancy blood glucose and insulin concentrations with DNA methylation in newborns.
Madelon L GeurtsenVincent W V JaddoeRomy GaillardJanine F FelixPublished in: Clinical epigenetics (2020)
Maternal early-pregnancy glucose concentrations, but not insulin concentrations, were associated with DNA methylation at one CpG each in the subgroups of normal weight and of overweight or obese women. No associations were present in the full group. The role of these CpGs in mechanisms underlying offspring health outcomes needs further study. Future studies should replicate our results in larger samples with early-pregnancy information on maternal fasting glucose metabolism.
Keyphrases
- blood glucose
- dna methylation
- glycemic control
- weight loss
- pregnancy outcomes
- type diabetes
- birth weight
- weight gain
- gene expression
- pregnant women
- genome wide
- gestational age
- bariatric surgery
- physical activity
- blood pressure
- metabolic syndrome
- body mass index
- health information
- copy number
- healthcare
- current status
- cord blood
- preterm infants