Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study.
Steven KhoLabibah QotrunnadaLeo LeonardoBenediktus AndriesPutu A I WardaniAurelie FricotBenoit HenryFabrice ChrétienNur I MargyaningsihDwi ApriyantiAgatha M PuspitasariPak PrayogaLeily TriantyEnny KenangalemFabrice ChretienValentine BrousseInnocent SafeukuiHernando A Del PortilloCarmen Fernandez-BecerraElamaran MeibalanMatthias MartiRichard N PriceTonia WoodberryPapa Alioune NdourBruce M RussellTsin Wen YeoGabriela MinigoRintis NoviyantiJeanne Rini PoespoprodjoNurjati C SiregarPierre A BuffetNicholas M AnsteyPublished in: PLoS medicine (2021)
Immature CD71+ reticulocytes and splenic P. vivax-infected erythrocytes of all asexual stages accumulate in the same splenic compartments, suggesting the existence of a cryptic endosplenic lifecycle in chronic P. vivax infection. Findings provide insight into P. vivax-specific adaptions that have evolved to maximise survival and replication in the spleen.