Complement gene mutations in children with C3 glomerulopathy: do they affect the response to mycophenolate mofetil?

Neslihan Günay İsmail Dursun Ibrahim Gokce Mehtap Akbalik Kara Demet Tekcan Neslihan Çiçek Meral Torun Bayram Mustafa Koyun Nida Dinçel Hasan Dursun Seha Kamil Saygili Zeynep Nagehan Yuruk Yildirim Selcuk Yuksel Osman Dönmez Sibel YelBeltinge Demircioğlu KılıçÖzlem Aydoğ Bahriye Atmis Aysun Çaltık Yılmaz Sevcan A Bakkaloglu Mehmet Baha Aytaç Mehmet Tasdemir Belde Kasap-Demir Alper Soylu Elif Çomak Aslı Kantar Özşahin Alper Kaçar Nur Canpolat Alev Yilmaz İlknur GirişgenKadirye Betül AkkoyunluHarika Alpay Muammer Hakan Poyrazoğlu

Published in: Pediatric nephrology (Berlin, Germany) (2023)

This study is the largest pediatric C3G study examining the relationship between genotype and phenotype. We showed that the mutation group often presented with asymptomatic urinary abnormalities, was diagnosed relatively late but was not different from the without mutation group in terms of MMF treatment response and kidney survival. A higher resolution version of the Graphical abstract is available as Supplementary information.

Keyphrases