Synthesis of Polysubstituted Furans through Electrochemical Selenocyclization of Homopropargylic Alcohols.

The current method represents an electrochemically driven synthetic route to access polysubstituted selenofuran derivatives through the diselenide-promoted cyclization of homopropargyl alcohols. The tandem electro-oxidative transformation operates at ambient temperature and in the absence of an external oxidant. This mild and efficient methodology exhibits good functional group compatibility, providing a broad range of substrate scopes up to 84% isolated yield. Further conversion of the seleno-functionality afforded other valuable furan derivatives.