Liposomal AntagomiR-155-5p restores anti-inflammatory macrophages and improves arthritis in pre-clinical models of Rheumatoid arthritis.

Audrey PaolettiBineta LyCatherine CailleauFan GaoMarie Péan de Ponfilly-SotierJuliette PascaudElodie RivièreLuxin YangLilian NwosuAziza ElmesmariFranceline ReynaudMagali HitaDavid PatersonJulien ReboudFrancois FayGaetane NocturneNicolas TsapisIain B McInnesMariola Kurowska-StolarskaElias FattalXavier Mariette

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

The injection of antagomiR-155-5p encapsulated in PEG-liposomes allows delivering small RNA to monocytes/macrophages, reduced joint inflammation in murine models of RA, providing a promising strategy in human disease.

Keyphrases

rheumatoid arthritis
anti inflammatory
disease activity
drug delivery
endothelial cells
oxidative stress
ankylosing spondylitis
interstitial lung disease
induced pluripotent stem cells
dendritic cells
drug release
nucleic acid