Colesevelam has no acute effect on postprandial GLP-1 levels but abolishes gallbladder refilling.
Ida M GetherEmilie BahneHenriette H NerildJens F RehfeldBolette HartmannJens J HolstTina VilsbøllDavid P SonneFilip K Krag KnopPublished in: European journal of endocrinology (2024)
Single-dose colesevelam had no effect on postprandial GLP-1 responses or glucose tolerance but disrupted postprandial gallbladder refilling by increasing CCK secretion and reducing circulating concentrations of FGF19 and bile acids. These findings leave the antidiabetic actions of colesevelam unresolved but provide mechanistic insights into its effect on gallbladder motility.