Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital setting.

Bih Hycenta Chendi Tracey Jooste Thomas Jens Scriba Martin Kidd Simon C Mendelsohn Kristian Tonby Katharina Ronacher Anne Margarita Dyrhol-Riise Novel Njweipi Chegou

Published in: Infectious diseases (London, England) (2022)

The three-genes signature may have potential to improve diagnosis of TB in a hospitalised low-burden setting. However, the influence of confounding variables or covariates such as age requires further evaluation in larger studies.

Keyphrases

mycobacterium tuberculosis
genome wide
genome wide identification
healthcare
adverse drug
single cell
copy number
dna methylation
risk factors
gene expression
rna seq
genome wide analysis
hiv infected
human health
antiretroviral therapy