Instability of harmonized thyroid-stimulating hormone immunoassays in clinical practice.

Kenichi UtoHironori BandoHidenori FukuokaMasaaki YamamotoAyako OgasaharaShoko OnoChinami OyabuItsuko SatoTakamitsu ImanishiJun SaegusaWataru OgawaYoshihiko Yano

Published in: Clinical endocrinology (2023)

We have confirmed that TSH harmonization in clinical practice is relatively stable. However, some patients showed deviating TSH levels in the harmonized TSH immunoassays, indicating the need for caution, particularly in poorly nourished patients. This finding suggests the presence of factors that contribute to the instability of TSH harmonization in such cases. Further investigation is warranted to validate these results.

Keyphrases

clinical practice
end stage renal disease
newly diagnosed
ejection fraction
prognostic factors