A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6.

Lu WangJiahui ZhouChuan ZhangRanran ChenQingyang SunPeng YangChaofan PengYuqian TanChi JinTuo WangJiangzhou JiYueming Sun

Published in: Clinical and translational medicine (2022)

In summary, we reported for the first time that circMAPK14 functioned as a tumour-suppressor by encoding circMAPK14-175aa, which blocked the progression and metastasis of colorectal cancer.

Keyphrases

protein protein
binding protein
amino acid