Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.
Shinichi FukudaSiddharth NarendranAkhil VarshneyYosuke NagasakaShao-Bin WangKameshwari AmbatiIvana ApicellaFelipe PereiraBenjamin J FowlerTetsuhiro YasumaShuichiro HiraharaReo YasumaPeirong HuangPraveen YerramothuRyan D MakinMo WangKirstie L BakerKenneth M MarionXiwen HuangElmira BaghdasaryanMeenakshi AmbatiVidya L AmbatiDaipayan BanerjeePreenie deS SenanayakeGenrich V TolstonogUlrike HeldYuichiro OguraHiroko TerasakiTetsuro OshikaDeepak BhattaraiKyung Bo KimSanford H FeldmanJose Ignacio AguirreDavid R HintonNagaraj KerurSrinivas R SaddaGerald G SchumannBradley D GelfandJayakrishna AmbatiPublished in: Science advances (2021)
[Figure: see text].