Synthesis of trifluoromethylthioesters from aldehydes via a visible light-promoted radical process.
Meng-Yue WangXue-Qing ZhuXing-Long ZhangRui-Li GuoQiong JiaYong-Qiang WangPublished in: Organic & biomolecular chemistry (2022)
We report herein an efficient, economical, and scalable trifluoromethylthiolation of aldehydes to generate trifluoromethylthioesters via a visible light-promoted radical process. The transformation features cheap reagents, simple operation, a broad substrate scope, and especially no metal involved in the reaction. Trifluoromethylthiolations of several complex aldehyde-containing bioactive compounds have been realized; thus the approach has the potential to be an important tool for the late-stage functionalization of advanced synthetic intermediates and bioactive molecules, and should have many applications in medicinal chemistry.
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