Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles.
Fateme Davarani AslMarziyeh MousazadehShirinsadat TajiAbbas BahmaniPatricia KhashayarMostafa AzimzadehEbrahim MostafaviPublished in: Nanomedicine (London, England) (2023)
AIDS causes increasing mortality every year. With advancements in nanomedicine, different nanomaterials (NMs) have been applied to treat AIDS and overcome its limitations. Among different NMs, nanoparticles (NPs) can act as nanocarriers due to their enhanced solubility, sustained release, targeting abilities and facilitation of drug-dose reductions. This review discusses recent advancements in therapeutics for AIDS/HIV using various NMs, mainly focused on three classifications: polymeric, liposomal and inorganic NMs. Polymeric dendrimers, polyethylenimine-NPs, poly(lactic-co-glycolic acid)-NPs, chitosan and the use of liposomal-based delivery systems and inorganic NPs, including gold and silver NPs, are explored. Recent advances, current challenges and future perspectives on the use of these NMs for better management of HIV/AIDS are also discussed.
Keyphrases
- gold nanoparticles
- antiretroviral therapy
- hiv aids
- drug delivery
- silver nanoparticles
- cancer therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- drug release
- oxide nanoparticles
- type diabetes
- cardiovascular disease
- hepatitis c virus
- hyaluronic acid
- coronary artery disease
- risk factors
- hiv testing
- men who have sex with men
- water soluble
- perovskite solar cells