Urinary phenotyping of SARS-CoV-2 infection connects clinical diagnostics with metabolomics and uncovers impaired NAD + pathway and SIRT1 activation.

Caterina LonatiGeorgy BerezhnoyNathan LawlerReika MasudaAditi KulkarniSamuele SalaPhilipp NitschkeLaimdota ZizmareDaniele BucciClaire CannetHartmut SchäferYogesh SinghNicola GraySamantha LodgeJeremy NicholsonUta MerleJulien WistChristoph Trautwein

Published in: Clinical chemistry and laboratory medicine (2023)

/SIRT1, offering a novel mechanism through which SARS-CoV-2 manipulates host physiology.

Keyphrases

sars cov
respiratory syndrome coronavirus
oxidative stress
ischemia reperfusion injury
mass spectrometry
high throughput
coronavirus disease