MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders.
Seyed Hamidreza Rastegar-MoghaddamAlireza Ebrahimzadeh-BideskanSara ShahbaAmir Mohammad MalvandiAbbas MohammadipourPublished in: Molecular neurobiology (2022)
MicroRNAs (miRs) are regulatory RNAs with 18-25 nucleotides lengths involved in various biological processes. Some miRs, including miR-22, play an essential role in regulating neurological disorders. MiR-22 is a brain-enriched regulatory element involved in angiogenesis, energy supply, adjustment of ionic channels, and suppression of malignant cell proliferation, migration, and invasion. This article discusses the protective and therapeutic effects of miR-22 on neurological diseases and injuries, including cerebral ischemia, neurodegenerative diseases, epilepsy, and brain malignancies. We also correlated miR-22 with amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), panic disorders, schizophrenia, neural tube defect (anencephaly), and traumatic brain injury. This work provides a therapeutic perspective for miR-22 as a new approach in treating neurological disorders.
Keyphrases
- cell proliferation
- cerebral ischemia
- long non coding rna
- multiple sclerosis
- long noncoding rna
- traumatic brain injury
- amyotrophic lateral sclerosis
- subarachnoid hemorrhage
- cell cycle
- blood brain barrier
- brain injury
- white matter
- pi k akt
- small molecule
- endothelial cells
- resting state
- mass spectrometry
- wound healing
- soft tissue