P2X7 receptor inhibition prevents atrial fibrillation in rodent models of depression.

Tianxin YeYunping ZhouJinxiu YangFangcong YuZhuonan SongJiaran ShiLongbo Wang Zhou-Qing HuangBo YangXingxiang Wang

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)

LPS or CUS induces AF and promotes P2X7R-dependent activation of NLRP3 inflammasome, whereas pharmacological P2X7R inhibition or P2X7R genetic deficiency prevents atrial remodelling without interrupting normal atrial physiological functions. Our results point to P2X7R as an important factor in the pathology of AF in depression.

Keyphrases

atrial fibrillation
nlrp inflammasome
catheter ablation
left atrial
oral anticoagulants
left atrial appendage
depressive symptoms
direct oral anticoagulants
heart failure
sleep quality
percutaneous coronary intervention
inflammatory response
mouse model
anti inflammatory
left ventricular