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"Apple does not fall far from the tree" - subclinical atherosclerosis in children with familial hypercholesterolemia.

Michał PodgórskiKatarzyna SzatkoMałgorzata StańczykMonika Pawlak-BratkowskaAgnieszka KonopkaEwa StarosteckaMarcin TkaczykSebastian GórecznyLena RutkowskaAgnieszka GachMaciej ŁukaszewskiPiotr GrzelakMaciej Banach
Published in: Lipids in health and disease (2020)
Children with FH presented subclinical atherosclerosis manifested as decreased arterial wall elasticity. Degree of stiffening was associated with advancement of atherosclerosis in their parents but did not present significant association with gene variants. Sonography with application of 2DST seems to be a good candidate for comprehensive evaluation of atherosclerosis in families with FH.
Keyphrases
  • cardiovascular disease
  • young adults
  • copy number
  • genome wide
  • type diabetes
  • magnetic resonance imaging
  • magnetic resonance
  • dna methylation
  • transcription factor