Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment.

Susannah L HewittDyane BaileyJohn ZielinskiAmeya ApteFaith MusengeRussell KarpShannon BurkeFabien GarconAnkita MishraSushma GurumurthyAmanda WatkinsKristen ArnoldJames MoynihanEleanor Clancy-ThompsonKathy MulgrewGrace AdjeiKatharina DeschlerDarren PotzGordon MoodyDavid A LeinsterSteven J NovickMichal SulikowskiChristopher J BagnallPhilip MartinJean-Martin LapointeHan SiChris MorehouseMaja SedicRobert W WilkinsonRonald HerbstJoshua P FrederickNadia Luheshi

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These data demonstrate the potential for intratumorally delivered IL12 mRNA to promote TH1 TME transformation and robust antitumor immunity.See related commentary by Cirella et al., p. 6080.

Keyphrases

binding protein
electronic health record
big data
machine learning
bone marrow