Crystal structures of cocrystals of 2,7-dihydroxynaphthalene with isoniazid and piracetam.
Juan Saulo González-GonzálezMiguel Eulalio Valiente FloresMarcos Flores-ÁlamoElizabeth Macías-LópezFrancisco Javier Martínez-MartínezNorberto FárfanPublished in: Acta crystallographica. Section C, Structural chemistry (2022)
Cocrystals of 2,7-dihydroxynaphthalene (DHN, or naphthalene-2,7-diol) with isoniazid (pyridine-4-carbohydrazide) (INH), denoted DHN-INH [C 10 H 8 O 2 ·C 6 H 7 N 3 O, (I)], and piracetam [2-(2-oxopyrrolidin-1-yl)acetamide] (PIR), denoted DHN-PIR [C 10 H 8 O 2 ·C 6 H 10 N 2 O 2 , (II)], were obtained by the solvent-assisted grinding method and characterized by IR spectroscopy, powder X-ray diffraction and single-crystal X-ray diffraction. Cocrystal (I) crystallized in the triclinic space group P-1 and showed a 2:2 stoichiometry. DHN and INH molecules are connected by O-H...N(pyridine) and O-H...N(hydrazide) hydrogen bonds. Cocrystal (II) crystallized in the space group Pca2 1 with a 1:1 stoichiometry. DHN and PIR molecules are connected by O-H...O=C hydrogen bonds. The supramolecular architecture of cocrystal (I) showed interlinked supramolecular tapes; meanwhile, in cocrystal (II), interlinked supramolecular sheets were observed.