New Sorbicillinoids from the Mangrove Endophytic Fungus Trichoderma reesei SCNU-F0042.

Jialin LiTao ChenJianchen YuHao JiaChen ChenYuhua Long

Published in: Marine drugs (2023)

Three new dimeric sorbicillinoids ( 1 - 3 ) and one new 3,4,6-trisubstituted α-pyrone ( 5 ), along with seven analogues ( 4 and 6 - 11 ), were isolated from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042 under the guidance of molecular networking approach. Their chemical structures were established by 1D and 2D NMR HR-ESI-MS and ECD analysis. In a bioassay, compound 2 exhibited moderate SARS-CoV-2 inhibitory activity with an EC 50 value of 29.0 μM.

Keyphrases

sars cov
ms ms
high resolution
mass spectrometry
magnetic resonance
multiple sclerosis
respiratory syndrome coronavirus
high intensity
molecular docking
solid state
molecular dynamics simulations
data analysis