TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
Wen-Jing ZhongJun ZhangJia-Xi DuanChen-Yu ZhangSheng-Chao MaYu-Sheng LiNan-Shi-Yu YangHui-Hui YangJian-Bing XiongCha-Xiang GuanZhi-Xing JiangZhi-Jian YouYong ZhouPublished in: Journal of translational medicine (2023)
In this study, we reported that TREM-1 acted as a necroptotic stimulus of AlvMs, fueling inflammation and aggravating ALI. We also provided compelling evidence suggesting that mTOR-dependent mitochondrial fission is the underpinning of TREM-1-triggered necroptosis and inflammation. Therefore, regulation of necroptosis by targeting TREM-1 may provide a new therapeutic target for ALI in the future.