Plasma extracellular vesicles and cell-free mitochondrial DNA are associated with cognitive dysfunction in treated older adults with HIV.
Carrie D JohnstonErika G Marques de MenezesScott BowlerEugenia L SieglerCourtney FridayPhilip J NorrisMichelle C RiceMary E ChoiMarshall J GlesbyLishomwa C NdhlovuPublished in: Journal of neurovirology (2023)
Extracellular vesicles (EVs) are nanoparticles with a role in intercellular communication. Cell-free mitochondrial DNA (cf-mtDNA) has been associated with cognitive dysfunction in people with HIV (PWH). We conducted a nested case-control study to test the hypothesis that plasma EVs are associated with cf-mtDNA and cognitive dysfunction in older PWH. A machine learning-based model identified total EVs, including select EV subpopulations, as well as urine cf-mtDNA and 4-meter walk time carry power to predict the neurocognitive impairment. These features resulted in an AUC-ROC of 0.845 + / - 0.109 (0.615, 1.00).
Keyphrases
- mitochondrial dna
- cell free
- copy number
- cystic fibrosis
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- machine learning
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- circulating tumor
- physical activity
- genome wide
- south africa
- artificial intelligence
- bipolar disorder
- dna methylation
- community dwelling
- cell adhesion
- circulating tumor cells