Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2.

Jason NomburgMatthew MeyersonJames A Decaprio

Published in: Genome medicine (2020)

We identify canonical and non-canonical junctions in SARS-CoV-2 sgRNAs and show that these RNA products are consistently generated by many independent viral isolates and sequencing approaches. These analyses highlight the diverse transcriptional activity of SARS-CoV-2 and offer important insights into SARS-CoV-2 biology.

Keyphrases

sars cov
respiratory syndrome coronavirus
single cell
single molecule
heat shock