Atipamezole, a specific α2A antagonist, suppresses spike-and-wave discharges and alters Ca2⁺ /calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats.

Melis Yavuz Banu Aydin Nihan Çarçak Özlem Akman Hasan Raci Yananlı Filiz Onat

Published in: Epilepsia (2020)

This study emphasizes the α2 AR-related modulation of absence epilepsy and particularly the significance of α2 AR antagonism in suppressing SWDs. Atipamezole's SWD-suppressive actions may be through CaMKII-mediated second messenger systems in the thalamus.

Keyphrases

protein kinase
signaling pathway
deep brain stimulation
genome wide
gene expression
dna methylation
temporal lobe epilepsy
drug induced