Antagonists of the serotonin receptor 5A target human breast tumor initiating cells.
William D GwynneMirza S ShakeelAdele Girgis-GabardoKwang H KimEmily FordAnna Dvorkin-GhevaCraig AartsMethvin IsaacRima Al-AwarJohn A HassellPublished in: BMC cancer (2020)
Our data provide genetic, pharmacological and phosphoproteomic evidence consistent with the on-target activity of SB-699551. The use of such agents in combination with cytotoxic chemotherapy provides a novel therapeutic approach to treat breast cancer.
Keyphrases
- induced apoptosis
- endothelial cells
- cell cycle arrest
- electronic health record
- genome wide
- locally advanced
- endoplasmic reticulum stress
- cell death
- copy number
- gene expression
- signaling pathway
- squamous cell carcinoma
- young adults
- dna methylation
- machine learning
- data analysis
- rectal cancer
- chemotherapy induced
- childhood cancer