Safety of combined ablative radiotherapy and immune checkpoint inhibitors in three phase I trials.

Connor LynchMark C KorpicsRohan R KatipallyChristine M BestvinaSean P PitrodaJyoti D PatelJason J LukeSteven J ChmuraAditya Juloori

Published in: European journal of cancer (Oxford, England : 1990) (2024)

This analysis features the largest prospectively evaluated cohort of patients treated with combination ablative SBRT and ICI to date and provides context for future trial design. We conclude that multi-site SBRT and ICI can be safely co-administered when SBRT is delivered with prioritization of normal tissue constraints.

Keyphrases

radiation therapy
locally advanced
radiation induced
early stage
clinical trial
current status
phase ii
squamous cell carcinoma