Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis.

Yiqiang HuRanyang TaoLang ChenYuan XiongHang XueLiangcong HuChenchen YanXudong XieZe LinAdriana C PanayiBobin MiGuohui Liu

Published in: Journal of nanobiotechnology (2021)

PGZ-Exos accelerated diabetic wound healing by promoting the angiogenic function of HUVECs through activation of the PI3K/AKT/eNOS pathway. This offers a promising novel cell-free therapy for treating diabetic wound healing.

Keyphrases

wound healing
cell free
mesenchymal stem cells
nitric oxide synthase
bone marrow
signaling pathway