Login / Signup

Diet-induced inflammation in the anterior paraventricular thalamus induces compulsive sucrose-seeking.

Jingjing ChengXiaolin MaChunlu LiRahim UllahXiaoyu WangJianmei LongZhenxin YuanShuangshuang LiuJunfen FuZhong ChenYi ShenYu-Dong Zhou
Published in: Nature neuroscience (2022)
Overconsumption of palatable food may initiate neuroadaptive responses in brain reward circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) consumption impedes threat-cue-induced suppression of sucrose-seeking in mice. This compulsive sucrose-seeking was due to enhanced cue-triggered neuronal activity in the anterior paraventricular thalamus (aPVT) resulting from HFD-induced microglia activation. Thus, metabolic inflammation in the aPVT produces an adaptive response to threat cues, leading to compulsive food-seeking.
Keyphrases