The prognostic impact of the immune microenvironment in small-cell neuroendocrine carcinoma of the uterine cervix: PD-L1 and immune cell subtypes.

Xiaoying Sun Li-Li Liu Ting Wan Qidan Huang Jieping Chen Rong-Zhen Luo Ji-Hong Liu

Published in: Cancer cell international (2022)

PD-L1 positivity was seen in over half of SCNEC tumors. It may work synergistically with FOXP3 + Treg and other infiltrating immune cells to support an adaptive immune response. PD-L1 positivity may be a favorable prognostic factor in SCNEC.

Keyphrases

prognostic factors
immune response
regulatory t cells
single cell
stem cells
cell therapy
preterm birth
inflammatory response
bone marrow