Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa.

Margaret M LoweJarish N CohenMadison I MossSean ClancyJames AdlerAshley YatesHaley B NaikMariela PauliIan TaylorAustin McKayHobart HarrisEsther KimScott L HansenMichael D RosenblumJoshua M Moreau

Published in: bioRxiv : the preprint server for biology (2023)

Our data definitively demonstrate the presence of TLS in lesional HS skin and point to ongoing cutaneous B cell maturation through class switch recombination and affinity maturation during disease progression in this inflamed non-lymphoid tissue.

Keyphrases

hidradenitis suppurativa
electronic health record
dna damage
dna repair
high resolution
big data
soft tissue
artificial intelligence
oxidative stress
data analysis