Impact of Changes of the 2020 Consensus Definitions of Invasive Aspergillosis on Clinical Trial Design: Unintended Consequences for Prevention Trials?

John R WingardBarbara D AlexanderLindsey R BadenMin ChenMichele W SugrueHelen L LeatherAngela M CaliendoCornelius J ClancyDavid W DenningFrancisco M MartyM Hong NguyenL Joseph WheatBrent R LoganMary M HorowitzKieren A Marr

Published in: Open forum infectious diseases (2021)

The updated IA consensus definitions may impact future trial designs, especially for antifungal prophylaxis studies.

Keyphrases

clinical trial
phase ii
phase iii
study protocol
clinical practice
candida albicans
open label
current status
double blind