Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice.
Irina V ZabbarovaYouko IkedaEvan J CarderPeter WipfAmanda S Wolf-JohnstonLori A BirderNaoki YoshimuraSamuel E GetchellKhalifa AlmansooriPradeep TyagiChristopher H FryMarcus J DrakeAnthony J KanaiPublished in: Neurourology and urodynamics (2018)
Drugs targeting p75NTRs can moderate DSD and DO in SCI mice, may identify pathophysiological mechanisms, and have therapeutic potential in SCI patients.
Keyphrases
- spinal cord injury
- end stage renal disease
- high fat diet induced
- spinal cord
- ejection fraction
- newly diagnosed
- cancer therapy
- neuropathic pain
- prognostic factors
- high glucose
- drug induced
- mouse model
- type diabetes
- insulin resistance
- adipose tissue
- oxidative stress
- high intensity
- skeletal muscle
- endothelial cells
- wild type