SARS CoV-2 infection as a risk factor of preeclampsia and pre-term birth. An interplay between viral infection, pregnancy-specific immune shift and endothelial dysfunction may lead to negative pregnancy outcomes.
Aleksander CelewiczMarta CelewiczMichał MichalczykPaula Woźniakowska-GondekKamila KrejczyMarcin MisiekRafał RzepkaPublished in: Annals of medicine (2023)
Knowledge of potential interplay between viral infection and physiological changes in pregnancy may point us in the direction of future prophylaxis and treatment in this special population.Key MessagesSARS-CoV-2 having affinity to ACE-2 and causing it's downregulation receptor may cause endothelial injury leading to compliment activation and formation of NETs, together with RAS dysregulation this may cause preeclampsia to develop in pregnant patients.PTB may occur in patients as an effect of SARS-CoV-2 infection in first or second trimester as an effect of TLR4 pathway dysregulation with lower levels of IFNβ.
Keyphrases
- pregnancy outcomes
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- pregnant women
- ejection fraction
- immune response
- peritoneal dialysis
- risk factors
- cell proliferation
- preterm infants
- early onset
- gestational age
- preterm birth
- sars cov
- respiratory syndrome coronavirus
- nuclear factor
- toll like receptor
- dendritic cells
- mass spectrometry
- coronavirus disease
- endothelial cells