Evaluation of Dosing Strategies of N-acetylcysteine for Acetaminophen Toxicity in Patients Greater than 100 Kilograms: Should the Dosage Cap Be Used?

Regan A Baum Jordan A Woolum Abby M BaileyMolly M HowellKyle A WeantLeeAnn GeraghtySanjay MohanAshley N WebbMark K SuPeter D Akpunonunull null

Published in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2021)

A capped NAC dosing scheme was not associated with higher rates of hepatic injury or hepatotoxicity in obese patients in the setting of acetaminophen poisoning when compared to a non-capped regimen. Further research is needed to verify these results.

Keyphrases

obese patients
end stage renal disease
bariatric surgery
ejection fraction
chronic kidney disease
newly diagnosed
liver injury
peritoneal dialysis
drug induced
prognostic factors
transcription factor
oxidative stress
patient reported outcomes