Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Jesús Madero-PérezElena FdezBelén FernándezAntonio J Lara OrdóñezMarian Blanca RamírezPatricia Gómez-SuagaDieter WaschbüschEvy LobbestaelVeerle BaekelandtAngus C NairnJavier Ruiz-MartínezAna AiastuiAdolfo López de MunainPawel LisThomas ComptdaerJean-Marc TaymansMarie-Christine Chartier-HarlinAlexandria BeilinaAdriano GonnelliMark R CooksonElisa GreggioSabine Hilfiker

Published in: Molecular neurodegeneration (2018)

Our findings reveal a new function of LRRK2 mediated by Rab8a phosphorylation and related to various centrosomal defects.

Keyphrases

parkinson disease
deep brain stimulation
protein kinase
genome wide
single cell
dna methylation
drug induced