Vasodilation of rat skeletal muscle arteries by the novel BK channel opener GoSlo is mediated by the simultaneous activation of BK and Kv 7 channels.
Olga ZavaritskayaSrikanth DudemDongyu MaKaneez E RababSarah AlbrechtDmitry TsvetkovMario KassmannKeith ThornburyMitko MladenovClaire KammermeierGerard SergeantNicholas MullinsOrnella WouappiHannah WurmAimo KanntMaik GollaschMark A HollywoodRudolf SchubertPublished in: British journal of pharmacology (2020)
This study shows that GoSlo-SR compounds are effective relaxants in vascular smooth muscle and mediate their effects by a combined activation of BK and Kv 7.4/Kv 7.5 channels. Activation of Kv 1, Kv 2 or Kv 7.1 channels or other vasodilator pathways seems not to be involved.