Platelet activation in critically ill COVID-19 patients.

Nader Yatim Jeremy BoussierRichard ChocronJérôme HadjadjAurélien PhilippeNicolas GendronLaura BarnabeiBruno CharbitTali-Anne SzwebelNicolas CarlierFrédéric PèneCélia AzoulayLina KhiderTristan MiraultJean-Luc DiehlCoralie L GuerinFrédéric Rieux-LaucatDarragh DuffySolen KernéisDavid M SmadjaBenjamin Terrier

Published in: Annals of intensive care (2021)

We provide evidence that platelets contribute to COVID-19 severity. Plasma sP-selectin level was associated with severity and in-hospital mortality. Transcriptional analysis identified PPBP/CXCL7 and SELPLG as biomarkers for intubation. These findings provide additional evidence for platelet activation in driving critical COVID-19. Specific studies evaluating the performance of these biomarkers are required.

Keyphrases

sars cov
coronavirus disease
respiratory syndrome coronavirus
gene expression
cardiac arrest
transcription factor
heat shock
case control
red blood cell