Phospho-inositide-dependent kinase 1 regulates signal dependent translation in megakaryocytes and platelets.

Bhanu Kanth ManneSeema BhatlekarElizabeth A MiddletonAndrew S WeyrichOliver BorstMatthew T Rondina

Published in: Journal of thrombosis and haemostasis : JTH (2020)

PDK1 is a previously unidentified translational regulator in MKs and platelets, controlling protein synthetic responses, proplatelet formation, and clot retraction.

Keyphrases

transcription factor
tyrosine kinase
red blood cell