Strontium-modified titanium substrate promotes osteogenic differentiation of MSCs and implant osseointegration via upregulating CDH2.

Chuan ZhouZiyu GeLu SongJiahui YanXinrui LangYanzhen ZhangFu-Ming He

Published in: Clinical oral implants research (2023)

The results indicated that CDH2 is required for Sr-SLA-mediated bone regeneration, which reveals a new mechanism to explain the osteoinductive effect of Sr-SLA. Thus, biomaterial modifications targeting CDH2 may help improve early osseointegration and bone healing.

Keyphrases

bone regeneration
soft tissue
mesenchymal stem cells
cancer therapy
bone mineral density
umbilical cord
bone marrow
structural basis