Gene Expression Profiling of Mediators Associated with the Inflammatory Pathways in the Intestinal Tissue from Patients with Ulcerative Colitis.
Gabriela Fonseca CamarilloEmilio Iturriaga GoyonRafael Barreto ZuñigaLucero Adriana Salazar SalasAna Elena Peredo EscárcegaJesus K Yamamoto-FurushoPublished in: Mediators of inflammation (2020)
: The gene expressions of FOXO4, ALDOB, SOD2, TOD2, SLC26A3, and SLC39A4 were associated with the clinical course and histological activity and are of relevance since these provide the utility of new prognostic markers in IBD. Gene expression signature showed dysregulation in mediators associated with autophagy, ubiquitination, ER stress, oxidative stress, carbohydrate metabolism, solute transport, and T cell regulation in the colonic mucosa from patients with UC, suggesting that these genes could be involved in the pathogenesis of UC.
Keyphrases
- gene expression
- ulcerative colitis
- oxidative stress
- dna methylation
- genome wide
- genome wide identification
- signaling pathway
- transcription factor
- cell death
- dna damage
- diabetic rats
- endoplasmic reticulum stress
- ischemia reperfusion injury
- copy number
- induced apoptosis
- single cell
- amyotrophic lateral sclerosis
- pi k akt
- genome wide analysis
- cell proliferation
- heat stress