Tumor-Targeting Peptide for Redox-Responsive Pt Prodrug and Gene Codelivery and Synergistic Cancer Chemotherapy.
Yaxuan BaiZeyu LiLiping LiuTiedong SunXiaocheng FanTing WangZhenzhen GouShengnan TanPublished in: ACS applied bio materials (2019)
A new codelivery system combining prodrug strategy, siRNA/BAplatin @CRGDK NPs, to overcome cisplatin (CDDP) resistance in human breast cancer was designed and researched. Negatively charged siRNA was deposited onto the surface of tumor-targeting peptide-functionalized BAplatin@CRGDK NPs. SiRNA/BAplatin@CRGDK NPs could facilitate cellular uptake of BAplatin and increase the cell proliferation suppression effect of Pt against MDA-MB-231/DDP cells. The tumor-to-kidney uptake ratio of the siRNA/BAplatin@CRGDK NPs in MB-231/DDP tumors is 2.4-fold higher than that of cisplatin in MB-231/DDP tumors, thus giving rise to more significant antitumor efficacy. It demonstrated that the siRNA/BAplatin@CRGDK NPs is a potential, safe, and efficient therapeutic agent for cancer therapy.
Keyphrases
- cancer therapy
- drug delivery
- cell proliferation
- oxide nanoparticles
- endothelial cells
- induced apoptosis
- squamous cell carcinoma
- genome wide
- radiation therapy
- oxidative stress
- gene expression
- signaling pathway
- copy number
- locally advanced
- quantum dots
- dna methylation
- breast cancer cells
- endoplasmic reticulum stress
- young adults
- rectal cancer
- transcription factor
- childhood cancer
- lymph node metastasis
- molecularly imprinted
- tandem mass spectrometry
- liquid chromatography